Article

Microglia mediate contact-independent neuronal pruning via secreted Neuraminidase-3 associated with extracellular vesicles

2023-08-21

Abstract excerpt

Neurons communicate with each other through electrochemical transmission at synapses. Microglia, the resident immune cells of the central nervous system, can prune these synapses through a variety of contact-dependent and -independent means. Microglial secretion of active sialidase enzymes upon exposure to inflammatory stimuli is one unexplored mechanism of pruning. Recent work from our lab showed that treatment o...

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Literature Corpus work: 9f5946ea-08c0-5bef-ac9f-6538bd01a081
DOI: 10.1101/2023.08.21.554214

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