Article

Neuroinflammation triggers microglial phagocytosis of synapses via induction of synaptic filopodia

2022-07-05

Abstract excerpt

<title>Abstract</title> <p>Activated microglia play a significant role in synaptic elimination during neuroinflammation, however, the events prior to the uptake of synaptic material by these cells remain elusive. Here, we performed in vivo two-photon imaging of microglia-synapse interactions in the context of systemic inflammation and Alzheimer´s disease. Both treatments induced microglial activation and decrease...

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Literature Corpus work: 5e0beac6-080f-5468-8f35-f050e042336d
DOI: 10.21203/rs.3.rs-1795055/v1

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