Article

Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization

2024-09-12

Abstract excerpt

<title>Abstract</title> <p>Background In mucopolysaccharidosis type III (MPS III), a pediatric neurodegenerative disorder, accumulation of abnormal glycosaminoglycans (GAGs) induces severe neuroinflammation by triggering the microglial pro-inflammatory cytokines production via a TLR4-dependent pathway. But the extent of the microglia contribution to the MPS III neuropathology remains unclear. Extracellular vesic...

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Literature Corpus work: 553ca192-4dcf-5ce8-983b-afd7c70eaa80
DOI: 10.21203/rs.3.rs-4869191/v1

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