Article

Sialylated Gangliosides are Required for Plasma Membrane Organization and Neuronal Function

2026-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Gangliosides are abundant neuronal glycosphingolipids, yet their roles in organizing the plasma membrane and supporting neuronal function remain poorly defined. Mutations in the biosynthetic enzymes ST3GAL5 or B4GALNT1 cause severe neurodevelopmental disorders, yet their cellular consequences are unclear. Using isogenic human iPSC-derived cortical neurons, we show that loss of these enzymes elim...

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Literature Corpus work: 9d279fb9-b499-568b-b58b-a3f126dec1a6
DOI: 10.64898/2026.03.18.712603

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