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Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization

2024-05-23

Abstract excerpt

<h4>Background</h4> In mucopolysaccharidosis type III (MPS III), a pediatric neurodegenerative disorder, accumulation of abnormal glycosaminoglycans (GAGs) induces severe neuroinflammation by triggering the microglial pro-inflammatory cytokines production via a TLR4-dependent pathway. But the extent of the microglia contribution to the MPS III neuropathology remains unclear. Extracellular vesicles (EVs) mediate i...

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Literature Corpus work
cd30f4bc-0ad3-59ec-88a9-d87878e4ae30
DOI
10.1101/2024.05.22.595318
Open publication

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Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborizationDOI 10.1101/2024.05.22.595318
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