Article

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes

2024-07-05

Abstract excerpt

Astrocytes participate in the clearance of obsolete or unwanted neuronal synapses. However, the molecular machinery involved in recognizing these synapses remains unclear, particularly under pathological conditions. Here, we investigated the phagocytic process of astrocytes through individual gene silencing with a druggable gene library. Our study demonstrates that astrocyte- mediated synapse engulfment is regulat...

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Literature Corpus work: 48b397c4-659d-5ee3-bb7e-c8fbbcda2d2b
DOI: 10.1101/2024.07.03.601867

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