Article

Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer’s Disease Models

2022-04-05

Abstract excerpt

Genetic studies implicate phagocytosis pathways in microglia to be a major Alzheimer’s disease (AD)-associated process. Microglia phagocytose synapses in AD mouse models, suggesting a role for microglia in region-specific synapse loss, a pathological hallmark of AD. However, whether specific synapses are targeted for elimination, and if so, how, remains to be elucidated. Here, we show that synapses externalize pho...

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Literature Corpus work: ab185f5a-fe56-5062-a6fd-28585f7c7f43
DOI: 10.1101/2022.04.04.486424

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