Article

Neuronal UBE3A loss engages a TNF-driven neuron-to-microglia axis that promotes synapse remodeling

2026-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Neuron–microglia communication shapes neuroimmune homeostasis and circuit maturation, yet the neuron-derived cues that tune microglial inflammatory state and phagocytic programs remain incompletely defined. The E3 ubiquitin ligase UBE3A is critical for brain development and synaptic function, and altered UBE3A dosage or activity is linked to neurodevelopmental phenotypes with emerging connection...

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Literature Corpus work: 144c466b-d2a8-5423-a624-bfbc5824cfbe
DOI: 10.64898/2026.05.27.728269

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