Article

Plasma Membrane Remodelling in GM2 Gangliosidoses Drives Synaptic Dysfunction

2024-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Glycosphingolipids (GSL) are important bioactive components of cellular membranes. Complex GSLs, containing sialic acid residues are known as gangliosides and are highly abundant in the brain. Diseases of ganglioside metabolism often result in severe, early-onset neurodegeneration. The ganglioside GM2 is the substrate of the hydrolytic lysosomal β- hexosaminidase A (HexA) enzyme and when subunit...

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Literature Corpus work: 1e111399-5fe1-5296-b8f4-a5069c108ccb
DOI: 10.1101/2024.08.20.608810

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