Article

Sodium/Potassium ATPase Alpha 1 Subunit Fine-tunes Platelet GPCR Signaling Function and is Essential for Thrombosis

2024-05-15

Abstract excerpt

<h4>Background</h4> Thrombosis is a major cause of myocardial infarction and ischemic stroke. The sodium/potassium ATPase (NKA), comprising α and β subunits, is crucial in maintaining intracellular sodium and potassium gradients. However, the role of NKA in platelet function and thrombosis remains unclear. <h4>Methods</h4> We utilized wild-type (WT, α 1 +/+ ) and NKA α1 heterozygous (α 1 +/- ) mice, aged 8 t...

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Literature Corpus work: 9f073548-b9c9-58f2-badb-d4f1c7049772
DOI: 10.1101/2024.05.13.593923

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