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Article

Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.

Circulation research - 5 Dec 2014

Li Wei, Gigante Alba, Perez-Perez Maria-Jesus, Yue Hong, Hirano Michio, McIntyre Thomas M, Silverstein Roy L

Abstract excerpt

RATIONALE: Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expressed in diseases with high risk of thrombosis, such as atherosclerosis and type II diabetes mellitus. OBJECTIVE: To test the hypothesis that TYMP participates in platelet signaling and promotes thrombosis. METHODS AND RESULTS: By using a ferric chloride (FeCl3)-induced carotid artery injury thrombosis model, we found time...

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Source

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Identifiers

PMID: 25287063
DOI: 10.1161/CIRCRESAHA.115.304591
PMCID: PMC4258140

Genes

TYMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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