Article
Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype.
Blood - 15 May 2003
Oury Cécile, Kuijpers Marijke J E, Toth-Zsamboki Emese, Bonnefoy Arnaud, Danloy Sophie, Vreys Ingrid, Feijge Marion A H, De Vos Rita, Vermylen Jos, Heemskerk Johan W M, Hoylaerts Marc F
Abstract excerpt
We have generated transgenic mice overexpressing the human P2X(1) ion channel in the megakaryocytic cell lineage. Platelets from transgenic mice exhibited a gain of P2X(1) ionotropic activity as determined by more prominent P2X(1)-mediated Ca(2+) influx and platelet shape change. P2X(1) overexpression enhanced platelet secretion and aggregation evoked by low doses of collagen, convulxin, or the thromboxane A(2)...
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