Article
Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk.
Blood - 16 Apr 2026
Yarman Yanki, Zhao Xuefei, Ahn Hyunsook, Thomson Hannah, Sarkar Amrita, Yuan Tian, Roberts Meghan, Wurtzel Jeremy G T, Diamond Scott L, Tesmer John J G, French Deborah L, Tomaiuolo Maurizio, Turro Ernest, Astle William J, Goldfinger Lawrence E, McKenzie Steven E, Benovic Jeffrey L, Stalker Timothy J, Poncz Mortimer, Ma Peisong
Abstract excerpt
ABSTRACT: Inherited genetic variants that modulate platelet function contribute significantly to thrombotic disorders, yet their mechanisms and clinical implications remain underexplored. Two genome-wide association studies identified an A→G variant (rs10886430) in the first intron of G protein-coupled receptor kinase 5 (GRK5), found in homozygosity in ∼5 million Americans. The homozygous GRK5 GG genotype is...
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