Article
A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling.
American journal of human genetics - 6 Aug 2020
Rodriguez Benjamin A T, Bhan Arunoday, Beswick Andrew, Elwood Peter C, Niiranen Teemu J, Salomaa Veikko, Trégouët David-Alexandre, Morange Pierre-Emmanuel, Civelek Mete, Ben-Shlomo Yoav, Schlaeger Thorsten, Chen Ming-Huei, Johnson Andrew D
Abstract excerpt
Dual antiplatelet therapy reduces ischemic events in cardiovascular disease, but it increases bleeding risk. Thrombin receptors PAR1 and PAR4 are drug targets, but the role of thrombin in platelet aggregation remains largely unexplored in large populations. We performed a genome-wide association study (GWAS) of platelet aggregation in response to full-length thrombin, followed by clinical association analyses,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.