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Article

Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?

Blood reviews - 1 Sept 2017

Nurden Alan T

Abstract excerpt

Glanzmann thrombasthenia (GT) is a rare inherited bleeding disorder caused by loss of αIIbβ3 integrin function in platelets. Most genetic variants of β3 also affect the widely expressed αvβ3 integrin. With brief mention of mouse models, I now look at the consequences of disease-causing ITGA2B and ITGB3 mutations on the non-hemostatic functions of platelets and other cells. Reports of arterial thrombosis in GT...

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Source

Identifiers

PMID: 28395882
DOI: 10.1016/j.blre.2017.03.005

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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