Article

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

2026-05-28

Abstract excerpt

<h4>Background</h4> The increase in human lifespan without a proportional increase in healthspan imposes a substantial burden on individuals and society. Exceptionally long-lived individuals and members of long-lived families exhibit compression of multi-morbidity. Genetics, and in particular rare protein-altering variants, appear to play an important role in their longevity. <h4>Methods</h4> In this study, we e...

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Literature Corpus work: 9efde9f3-40e2-5077-a9dc-c9d7585bf6fb
DOI: 10.64898/2026.05.28.728260

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Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across speciesDOI 10.64898/2026.05.28.728260Read

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