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Article

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.

GeroScience - 1 Feb 2026

Baghdadi Maarouf, Hinterding Helena, Gehrmann Thies, Putter Pasquale, Neuerburg Mara, Lakenberg Nico, van den Akker Erik B, Slagboom P Eline, Deelen Joris, Partridge Linda

Abstract excerpt

Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequencing data of long-lived individuals from the Leiden Longevity Study and identified family-specific variants residing in genes involved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40442464
DOI: 10.1007/s11357-025-01699-2
PMCID: PMC12972501

Genes

NF1
RAF1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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