Article

Evaluating the life-extending potential and safety profile of rapamycin: a Mendelian Randomization study of the mTOR pathway

2023-10-02

Abstract excerpt

<h4>Objective</h4> The mechanistic target of rapamycin (mTOR) pathway plays an integral role in cellular metabolism, growth, and aging. While rapamycin and its analogs inhibit the mTOR pathway, extending lifespan in various organisms, the long-term safety and efficacy of these compounds in humans remain understudied. <h4>Methods</h4> Utilizing two mTOR expression QTL instruments derived from the eQTLgen and MetaBr...

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Literature Corpus work: e299f84f-e821-5dad-afe4-e956266c9918
DOI: 10.1101/2023.10.02.23296427

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