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Article

Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2015

Morris Brian J, Donlon Timothy A, He Qimei, Grove John S, Masaki Kamal H, Elliott Ayako, Willcox D Craig, Allsopp Richard, Willcox Bradley J

Abstract excerpt

The mechanistic target of rapamycin (mTOR) pathway is crucial for life span determination in model organisms. The aim of the present study was to test tagging single-nucleotide polymorphisms that captured most of the genetic variation across key TOR complex 1 (TORC1) and TOR complex 2 (TORC2) genes MTOR, RPTOR, and RICTOR and the important downstream effector gene RPS6KA1 for association with human longevity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24589862
DOI: 10.1093/gerona/glu021
PMCID: PMC4366598

Genes

MTOR
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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