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Article

German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway.

GeroScience - 1 Jun 2025

Kolbe Daniel, Dose Janina, Putter Pasquale, Ziemann Malte, Laudes Matthias, Slagboom P Eline, Franke Andre, Deelen Joris, Nebel Almut

Abstract excerpt

In this study, we investigated the contribution of rare coding variants to human longevity by analyzing whole exome sequencing data from 1245 German long-lived individuals (LLI) and 4105 geographically matched younger controls. We identified novel exome-wide significant associations at both the single-variant and gene level, with a significant over-representation of genes involved in mechanistic target of...

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Identifiers

PMID: 40232348
DOI: 10.1007/s11357-025-01640-7
PMCID: PMC12181166

Genes

ASXL1
DNAJB13
FLCN
FOCAD
HOXA4
IHH
MESD
PRAC2
RPS6
RWDD1
SIK3
TET2

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