Article

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

2023-06-01

Abstract excerpt

Human longevity, which is coupled to a compression of age-related disease, has been shown to be heritable. However, the number of identified common genetic variants linked to this trait remains small. This may indicate that longevity is, at least to some extent, determined by rare genetic variants that are potentially family-specific. We therefore investigated whole-genome sequencing data of long-lived families fr...

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Literature Corpus work: 2cdedb52-ecf8-5d61-9162-92f068aff013
DOI: 10.1101/2023.06.01.541708

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