Article
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis.
Nature genetics - 1 Feb 2021
Wingo Aliza P, Liu Yue, Gerasimov Ekaterina S, Gockley Jake, Logsdon Benjamin A, Duong Duc M, Dammer Eric B, Robins Chloe, Beach Thomas G, Reiman Eric M, Epstein Michael P, De Jager Philip L, Lah James J, Bennett David A, Seyfried Nicholas T, Levey Allan I, Wingo Thomas S
Abstract excerpt
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's disease (AD)1,2, but how these loci confer AD risk is unclear. Here, we aimed to identify loci that confer AD risk through their effects on brain protein abundance to provide new insights into AD pathogenesis. To that end, we integrated AD GWAS results with human brain proteomes to perform a proteome-wide association study...
Topics
- Alzheimer Disease
- Apolipoproteins E
- Brain
- Epoxide Hydrolases
- Genome-Wide Association Study
- Humans
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Proteome