Article

Integrating GWAS and Transcriptomic Data Using PrediXcan and Multimodal Deep Learning Reveals Genetic Basis and Drug Repositioning Opportunities for Alzheimer’s Disease

2025-01-02

Abstract excerpt

Alzheimer’s disease (AD), the leading cause of dementia, imposes a significant societal and economic burden; however, its complex molecular mechanisms remain unclear. This study integrates multi-omics data with advanced artificial intelligence (AI) methods to uncover the molecular basis underlying AD phenotype regulation and explore personalized drug repositioning strategies based on individual genetic backgrounds...

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Literature Corpus work: 3a49b059-945e-54e7-8986-2fbd667b364d
DOI: 10.1101/2025.01.02.25319880

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