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Article

Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia.

American journal of human genetics - 5 Sept 2024

Hu Tingyang, Parrish Randy L, Dai Qile, Buchman Aron S, Tasaki Shinya, Bennett David A, Seyfried Nicholas T, Epstein Michael P, Yang Jingjing

Abstract excerpt

Transcriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing the underlying disease mechanisms better than GWAS loci....

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Identifiers

PMID: 39079537
DOI: 10.1016/j.ajhg.2024.07.001
PMCID: PMC11393696

Genes

APOC1
APOC2
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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