Article
Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia.
American journal of human genetics - 5 Sept 2024
Hu Tingyang, Parrish Randy L, Dai Qile, Buchman Aron S, Tasaki Shinya, Bennett David A, Seyfried Nicholas T, Epstein Michael P, Yang Jingjing
Abstract excerpt
Transcriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing the underlying disease mechanisms better than GWAS loci....
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