Article

Clonal memory of colitis accumulates and promotes tumor growth

2025-02-17

Abstract excerpt

Chronic inflammation is a well-established risk factor for cancer, but the underlying molecular mechanisms remain unclear. Using a mouse model of colitis, we demonstrate that colonic stem cells retain an epigenetic memory of inflammation following disease resolution, characterized by a cumulative gain of activator protein 1 (AP-1) transcription factor activity. Further, we develop SHARE-TRACE, a method that enable...

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Literature Corpus work: 9ef087ff-af7e-5316-9596-d55638553da6
DOI: 10.1101/2025.02.13.638099

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