Article

Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation

2025-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Intestinal epithelial damage and impaired repair are hallmarks of ulcerative colitis (UC), even after inflammation resolves. Intestinal stem cells (ISCs) can retain stable epigenetic changes after inflammation, highlighting the potential for long-lived epithelial memory in the gut. Inflammatory injury in barrier tissues induces epigenetic memory in epithelial stem cells, and the tendency of UC t...

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Literature Corpus work: 12e802c3-7ca2-558d-9fba-9359bd81469b
DOI: 10.1101/2025.05.24.655923

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