Article

Clonal memory of colitis accumulates and promotes tumor growth

2025-03-27

Abstract excerpt

<title>Abstract</title> <p>Chronic inflammation is a well-established risk factor for cancer, but the underlying molecular mechanisms remain unclear. Using a mouse model of colitis, we demonstrate that colonic stem cells retain an epigenetic memory of inflammation following disease resolution, characterized by a cumulative gain of activator protein 1 (AP-1) transcription factor activity. Further, we develop SHARE...

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Literature Corpus work: 8f82f7c7-12e6-5e99-ad20-b5dff64f5d17
DOI: 10.21203/rs.3.rs-6081101/v1

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