Article
Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis.
Nature genetics - 1 Aug 2026
Moutin Elisa B, Chang Linus L H, Giavara Giada, Mehmed Shenay, Colombé Mathilde, Boquetale Carla, Marks Kate, Lourenço Filipe C, Skoufou-Papoutsaki Nefeli, Kemp Richard, Gascard Philippe, Tlsty Thea D, Tourigny David S, Winton Douglas J
Abstract excerpt
In the progression from inflammatory bowel disease to associated cancer, the clonal mutational landscape shifts from selection of mutations in inflammatory genes to selection for cancer-driver mutations. How prevalence and expansion of either type of mutant clones could be impacted by the cellular environments in which they arise and how this affects the neoplastic outcome of colitis remains unknown. Here we...
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