Article

Inflammation-driven reprogramming of goblet cells underlies the onset of serrated adenomas in colon cancer

2026-06-23

Abstract excerpt

In the context of inflammation, fully committed and post-mitotic cell lineages can initiate intestinal tumorigenesis in the mouse through dedifferentiation and acquisition of revival stem cell (RSC) features 1,2 . Likewise, by means of machine-learning analysis of whole-genome mutation spectra, the secretory goblet cell was predicted as the most frequent cell-of-origin (COO) of colon cancer in inflammatory bowel...

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Literature Corpus work: edc5c563-7dbf-5c42-af83-243f68c76225
DOI: 10.64898/2026.06.22.733748

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