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Article

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

2022-11-01

Abstract excerpt

To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and DNA viruses are sensed are relevant not only to antiviral innate immunity, but also to autoinflammation and anti-tumour immunity through initiation of sterile inflammation by self-DNA reco...

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Identifiers and source

Literature Corpus work
2872f266-18bf-5cc9-8ae7-af16c70e847a
DOI
10.1101/2022.11.01.514678
Open publication

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DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cellsDOI 10.1101/2022.11.01.514678
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