Article

Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells

2022-06-23

Abstract excerpt

Modulation of T cell activity is an effective strategy for the treatment of autoimmune diseases, immune-related disorders and cancer. This highlights a critical need for continued investigation of proteins that regulate T cell function. The kinase DNA -dependent p rotein k inase c atalytic s ubunit (DNA-PKcs) is emerging as a potent regulator of the immune system spurring interest in its use as a therapeutic...

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Literature Corpus work: 76be9534-9aae-5977-ba37-b909c07a5f5f
DOI: 10.1101/2022.06.23.497236

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