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Article

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

23 Dec 2023

Abstract excerpt

To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and DNA viruses are sensed are relevant not only to anti-viral innate immunity, but also to autoinflammation and anti-tumour immunity through the initiation of sterile inflammation by...

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Identifiers

PMID: 38269102
DOI: 10.1016/j.isci.2023.108760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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