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DNA-PKcs: A Targetable Protumorigenic Protein Kinase

10 Dec 2021

Abstract excerpt

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic...

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Cancer-related Molecular Pathways
Chronic Lymphocytic Leukemia Research
DNA Repair Mechanisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34893509
DOI: 10.1158/0008-5472.can-21-1756

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