Machine-Guided Dual-Objective Protein Engineering for Deimmunization and Therapeutic Functions

Abstract excerpt

Cell and gene therapies often rely on the expression of exogenous proteins derived from nonhuman organisms. An emerging consensus is to reduce the potential immunogenicity of such therapies by instead using human protein domains. However, as we engineer these human-derived proteins, we create nonhuman peptides at the linkers or junctions between domains and at mutated residues within them, which still pose a risk...

Topics

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• Biosimilars and Bioanalytical Methods
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Monoclonal and Polyclonal Antibodies Research
• Toxin Mechanisms and Immunotoxins
• Transgenic Plants and Applications
• vaccines and immunoinformatics approaches
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

c8957609-f90c-56b5-9405-0dc74726ba78

DOI

10.1101/2025.02.24.639918