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A synthetic transcription platform for programmable gene expression in mammalian cells

18 Oct 2022

Abstract excerpt

Precise, scalable, and sustainable control of genetic and cellular activities in mammalian cells is key to developing precision therapeutics and smart biomanufacturing. Here we create a highly tunable, modular, versatile CRISPR-based synthetic transcription system for the programmable control of gene expression and cellular phenotypes in mammalian cells. Genetic circuits consisting of well-characterized libraries...

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PMID: 36257931
DOI: 10.1038/s41467-022-33287-9

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