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Caffeine-regulated molecular switches for functional control of CAR T cells <i>in vivo</i>

2025-06-13

Abstract excerpt

The limited controllability of CAR T cells in patients represents a key challenge of this highly potent immunotherapy. A molecular ON-switch, which can be regulated with a non-toxic and readily available small molecule drug, would represent a major advance towards controllable CAR T therapeutics. For that purpose, we engineered caffeine-responsive heterodimeric ON-switches (CaffSwitches) and demonstrate their high...

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Literature Corpus work
7dea86ce-b606-5653-aef1-023e0ec743c9
DOI
10.1101/2025.06.13.659487
Open publication

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Caffeine-regulated molecular switches for functional control of CAR T cells <i>in vivo</i>DOI 10.1101/2025.06.13.659487
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