Back to search

Article

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells

2020-12-11

Abstract excerpt

Precise, scalable, and sustainable control of genetic and cellular activities in mammalian cells is key to developing precision therapeutics and smart biomanufacturing. We created a highly tunable, modular, versatile CRISPR-based synthetic transcription system for the programmable control of gene expression and cellular phenotypes in mammalian cells. Genetic circuits consisting of well-characterized libraries of g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
99cf6e80-f61d-579a-b18c-0dd21320b0f4
DOI
10.1101/2020.12.11.420000
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian CellsDOI 10.1101/2020.12.11.420000
A synthetic transcription platform for programmable gene expression in mammalian cellsSemantic proximity
Multidimensional control of therapeutic human cell function with synthetic gene circuitsSemantic proximity
Clinically-driven design of synthetic gene regulatory programs in human cellsSemantic proximity
Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuliSemantic proximity
Programmable eukaryotic protein expression with RNA sensorsSemantic proximity
An integrated RNA and CRISPR/Cas toolkit for multiplexed synthetic circuits and endogenous gene regulation in human cellsSemantic proximity
Small-molecule inducible transcriptional control in mammalian cellsSemantic proximity
Cell-free transcriptional regulation via nucleic-acid-based transcription factorsSemantic proximity
CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular ProgrammingSemantic proximity
Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systemsSemantic proximity
Programming gene and engineered-cell therapies with synthetic biologySemantic proximity
Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuitsSemantic proximity
Select a neighboring publication to make it the new centre.