Article
Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2020
Geragotelis Andrew D, Wood Mona L, Göddeke Hendrik, Hong Liang, Webster Parker D, Wong Eric K, Freites J Alfredo, Tombola Francesco, Tobias Douglas J
Abstract excerpt
The voltage-gated Hv1 proton channel is a ubiquitous membrane protein that has roles in a variety of cellular processes, including proton extrusion, pH regulation, production of reactive oxygen species, proliferation of cancer cells, and increased brain damage during ischemic stroke. A crystal structure of an Hv1 construct in a putative closed state has been reported, and structural models for the channel open...
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