Article
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Cell reports - 3 Apr 2018
Knijnenburg Theo A, Wang Linghua, Zimmermann Michael T, Chambwe Nyasha, Gao Galen F, Cherniack Andrew D, Fan Huihui, Shen Hui, Way Gregory P, Greene Casey S, Liu Yuexin, Akbani Rehan, Feng Bin, Donehower Lawrence A, Miller Chase, Shen Yang, Karimi Mostafa, Chen Haoran, Kim Pora, Jia Peilin, Shinbrot Eve, Zhang Shaojun, Liu Jianfang, Hu Hai, Bailey Matthew H, Yau Christina, Wolf Denise, Zhao Zhongming, Weinstein John N, Li Lei, Ding Li, Mills Gordon B, Laird Peter W, Wheeler David A, Shmulevich Ilya, Monnat Raymond J, Xiao Yonghong, Wang Chen
Abstract excerpt
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair...
Topics
- Cell Line, Tumor
- DNA Damage
- Gene Silencing
- Genome, Human
- Humans
- Loss of Heterozygosity
- Machine Learning