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DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

12 Apr 2018

Abstract excerpt

Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1. Our spatially resolved interaction maps reveal rich network intricacies,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29656893
DOI: 10.1016/j.cell.2018.03.050

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