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Defective DNA repair: a putative nexus linking immunological diseases, neurodegenerative disorders, and cancer.

Mutagenesis - 15 Mar 2025

Andarawi Safaa, Vodickova Ludmila, Uttarilli Anusha, Hanak Petr, Vodicka Pavel

Abstract excerpt

DNA damage is a common event in cells, resulting from both internal and external factors. The maintenance of genomic integrity is vital for cellular function and physiological processes. The inadequate repair of DNA damage results in the genomic instability, which has been associated with the development and progression of various human diseases. Accumulation of DNA damage can lead to multiple diseases, such as...

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DNA Damage
DNA Repair
Genome-Wide Association Study
Genomic Instability
Immune System Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurodegenerative Diseases

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39937585
DOI: 10.1093/mutage/geae029

Genes

ATM
CUX2
RAD51B
WNT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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