Article

Putting Polygenic Scores in Context: How Intersectional Factors Affect Relative and Absolute Genetic Risk

2025-06-05

Abstract excerpt

<h4>Background</h4> The clinical utility of polygenic scores (PGS) is known to vary when training and test samples differ in ancestry, with recent work suggesting that sociodemographic differences can also impact PGS performance. However, the impact of belonging to multiple intersecting contexts on genetic risk remains understudied. <h4>Methods</h4> We analyzed lifetime disease odds ratios (OR) and absolute risks...

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Literature Corpus work: 9e5875a7-d6af-53f4-bbf9-898e3ad75183
DOI: 10.1101/2025.06.04.25328987

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