Article

Locus-specific gene-context interactions improve polygenic prediction

2026-08-28

Abstract excerpt

Polygenic scores (PGS) are a primary output of large-scale genetic studies and are being deployed in clinical and non-clinical settings. However, current PGS assume simple additive models that ignore context-specific genetic effects, which likely reduce their accuracy and robustness. To address this, we developed PGSC, a PGS framework to incorporate locus-specific gene-context interaction effects (GxC). Simulation...

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Literature Corpus work: fd41db44-c7f5-50d9-88db-4770330502b6
DOI: 10.64898/2026.08.26.746823

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