Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk.

American journal of human genetics - 7 May 2026

Cudic Mihael, Tubbs Justin D, Ge Tian, Smoller Jordan W

Abstract excerpt

The clinical utility of polygenic scores (PGSs) is known to vary when training and test samples differ in ancestry, with recent work suggesting that sociodemographic differences can also impact PGS performance. However, the impact of belonging to multiple intersecting contexts on genetic risk remains understudied. We analyzed lifetime disease odds ratio (OR) and absolute risk (AR) estimates in high-PGS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Artery Disease
Share to European People
Share to Genetic Risk Score

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypercholesterolemia

Share to Major Depressive Disorder

Share to Multifactorial Inheritance

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 41980777
DOI: 10.1016/j.ajhg.2026.03.013
PMCID: PMC13120731

Genes

AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk.PMID 41980777Read ↗

Putting Polygenic Scores in Context: How Intersectional Factors Affect Relative and Absolute Genetic RiskSemantic proximity Read ↗

Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions.Semantic proximity Read ↗

Bridging the Genomic Equity Gap with Context-Enhanced Risk Stratification in American Indians: the Strong Heart StudySemantic proximity Read ↗

Calibrated prediction intervals for polygenic scores across diverse contexts.Semantic proximity Read ↗

Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease riskSemantic proximity Read ↗

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.Semantic proximity Read ↗

Optimization of Multi-Ancestry Polygenic Risk Score Disease Prediction ModelsSemantic proximity Read ↗

All of Us diversity and scale improve polygenic prediction contextually with greatest improvements for under-represented populationsSemantic proximity Read ↗

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsSemantic proximity Read ↗

Current clinical use of polygenic scores will risk exacerbating health disparitiesSemantic proximity Read ↗

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores.Semantic proximity Read ↗

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.