Article

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

2000-03-14

Abstract excerpt

The TCL1 oncogene at 14q32.1 is involved in the development of human mature T-cell leukemia. The mechanism of action of Tcl1 is unknown. Because the virus containing the v-akt oncogene causes T-cell lymphoma in mice and Akt is a key player in transduction of antiapoptotic and proliferative signals in T-cells, we investigated whether Akt and Tcl1 function in the same pathway. Coimmunoprecipitation experiments showe...

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Literature Corpus work: 9e4687b1-3e7d-5c76-88cf-36aceb1bf77a
DOI: 10.1073/pnas.97.7.3028

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