Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Central role of PI3K in transcriptional activation of hTERT in HTLV-I–infected cells

29 May 2008

Abstract excerpt

The persistence of human T-cell leukemia/lymphoma virus-I (HTLV-I)-infected cells is dependent upon clonal expansion and up-regulation of telomerase (hTERT). We have previously found that in interleukin (IL)-2-independent transformed HTLV-I cells, Tax strongly activates the hTERT promoter through nuclear factor-kappaB (NF-kappaB)-mediated Sp1 and c-Myc activation. In IL-2-dependent cells and adult T-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to T-cell and Retrovirus Studies
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18511807
DOI: 10.1182/blood-2008-01-134692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Central role of PI3K in transcriptional activation of hTERT in HTLV-I–infected cellsPMID 18511807Read ↗

Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cellsSemantic proximity Read ↗

Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth.Semantic proximity Read ↗

JAK–STAT and JAK–PI3K–mTORC1 Pathways Regulate Telomerase Transcriptionally and Posttranslationally in ATL CellsSemantic proximity Read ↗

Molecular mechanisms of cellular transformation by HTLV-1 Tax.Semantic proximity Read ↗

IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.Semantic proximity Read ↗

Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T lymphocytes.Semantic proximity Read ↗

Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.Semantic proximity Read ↗

HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains.Semantic proximity Read ↗

Tcl1 enhances Akt kinase activity and mediates its nuclear translocationSemantic proximity Read ↗

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Semantic proximity Read ↗

Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear TranslocationSemantic proximity Read ↗

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.