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Article

Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies

8 Nov 2011

Abstract excerpt

The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias. TCL1 dysregulation in B cells is responsible for the development of an aggressive form of chronic lymphocytic leukemia (CLL), the most common human leukemia. We have investigated the mechanisms underlying the oncogenic...

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Identifiers

PMID: 22065599
DOI: 10.1182/blood-2011-08-374561

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Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignanciesPMID 22065599Read ↗

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