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Article

Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression

10 Apr 2014

Abstract excerpt

BACKGROUND: The phosphatidylinositol 3-kinase-regulated protein kinase, Akt, plays an important role in the initiation and progression of human cancer. Mammalian cells express three Akt isoforms (Akt1-3), which are encoded by distinct genes. Despite sharing a high degree of amino acid identity, phenotypes observed in knockout mice suggest that Akt isoforms are not functionally redundant. The relative...

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PMID: 24722238
DOI: 10.1371/journal.pone.0094595

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