Article
Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
Oncogene - 1 Jul 2010
Guo G, Qiu X, Wang S, Chen Y, Rothman P B, Wang Z, Chen Y, Wang G, Chen J-L
Abstract excerpt
Abl-mediated transformation requires the activation of multiple pathways involved in the cellular proliferation and survival, including PI3K/AKT and JAK/STAT-dependent Pim kinases. Recently, the E17K mutation in the AKT1 has been associated with multiple human malignancies and leukemia in mice. However, this mutation has not been identified in Abl-transformed cells. We investigated the presence of the AKT1(E17K)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.