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Article

Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.

Experimental cell research - 15 May 2007

Hinton Cimona V, Fitzgerald Latricia D, Thompson Marilyn E

Abstract excerpt

Signaling pathways involved in regulating nuclear-cytoplasmic distribution of BRCA1 have not been previously reported. Here, we provide evidence that heregulin beta1-induced activation of the Akt pathway increases the nuclear content of BRCA1. First, treatment of T47D breast cancer cells with heregulin beta1 results in a two-fold increase in nuclear BRCA1 as assessed by FACS analysis, immunoblotting and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17428466
DOI: 10.1016/j.yexcr.2007.03.008
PMCID: PMC1939819

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.PMID 17428466Read ↗

Targeting the Akt/mTOR pathway in Brca1-deficient cancers.Semantic proximity Read ↗

Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells.Semantic proximity Read ↗

Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Semantic proximity Read ↗

Tcl1 enhances Akt kinase activity and mediates its nuclear translocationSemantic proximity Read ↗

Aberrant subcellular localization of BRCA1 in breast cancer.Semantic proximity Read ↗

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.Semantic proximity Read ↗

Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.Semantic proximity Read ↗

Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci.Semantic proximity Read ↗

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.Semantic proximity Read ↗

Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells.Semantic proximity Read ↗

Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells.Semantic proximity Read ↗

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.Semantic proximity Read ↗

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